New Sphingolipids from Marine Sponge Iotrochota baculifera

Marine bifunctional sphingolipids from the sponge Oceanapia ramsayi.

During the course of our continuing studies on marine natural lipid products,two known sphingolipids have been isolated for the first time from a specimen of the marine sponge Oceanapia ramsayi collected at Itampolo on the west coast of Madagascar in the Indian Ocean. The structures were elucidated using NMR data and by comparison with literature data. The occurrence of these sphingolipids with...

Graphical Abstract Antitrypanosomal iotrochamides A and B from the Australian marine sponge Iotrochota sp

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota

Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.

Bioassay-guided isolation of the CH(2)Cl(2)/MeOH extract from the Australian sponge Iotrochota sp. resulted in the purification of two new N-cinnamoyl-amino acids, iotrochamides A (1) and B (2). The chemical structures of 1 and 2 were determined by 1D/2D NMR and MS data analyses. Compounds 1 and 2 were shown to inhibit Trypanosoma brucei brucei with IC(50) values of 3.4 and 4.7 μM, respectively.

Antioxidant alkaloid from the South China Sea marine sponge Iotrochota sp.

Purpurone was isolated from the sponge Iotrochota sp. by bioactivity-guided fractionation. The compound showed antioxidant activity using the DPPH assay. The structure was established on the basis of NMR data and comparison with data reported.